Hiranuma COM-A19 Automatic Potentiometric Titrator

Overview

The Hiranuma COM-A19 Automatic Potentiometric Titrator is an engineered solution for precise, reproducible, and operator-independent potentiometric titrations in regulated laboratory environments. Based on the fundamental principle of measuring potential difference (in millivolts) between a reference electrode and an indicator electrode as titrant is incrementally delivered, the COM-A19 enables endpoint detection via first-derivative (ΔE/ΔV) or second-derivative (Δ²E/ΔV²) analysis of the titration curve. Its −2000 to +2000 mV measurement range accommodates redox, acid-base, precipitation, and complexometric titrations across diverse sample matrices — from aqueous pharmaceutical formulations to industrial process streams and environmental extracts. Designed for compliance-driven workflows, the instrument supports audit-ready operation through timestamped data logging, user-access control, and traceable method execution.

Key Features

• 8.4-inch high-resolution color TFT-LCD touchscreen with 16-step mechanical tilt adjustment — optimized for ergonomic viewing under variable lab lighting and bench configurations.
• Integrated voice feedback system providing real-time audible status announcements (e.g., “Titration started”, “Endpoint detected”, “Printer ready”), enabling hands-free monitoring without visual proximity.
• Plug-and-play titration head module with quick-release mechanism — allows full reagent cartridge replacement using one hand, minimizing cross-contamination risk and downtime during multi-method runs.
• 40-step digitally controlled magnetic stirrer with continuous forward/reverse rotation capability — ensures homogeneous mixing for viscous, heterogeneous, or gas-evolving samples while preventing vortex formation or electrode shielding.
• Dual-status LED indicators: bi-color operational light (green/amber/red) for immediate local status recognition; tri-color system status light (blue/green/red) for remote visual confirmation of standby, active, or error conditions.
• Built-in thermal printer (58 mm paper width) with automatic print-on-completion functionality — generates hard-copy reports including method ID, sample ID, titrant concentration, consumed volume, endpoint mV, and calculated result with units.
• Standard USB host port for direct data export to flash drives and optional LAN interface enabling browser-based remote access (HTTP/HTTPS), real-time status viewing, and firmware updates without dedicated client software.

Sample Compatibility & Compliance

The COM-A19 is validated for use with standard double-junction reference electrodes (e.g., Ag/AgCl/KCl 3 M) and application-specific indicator electrodes (e.g., pH glass, redox Pt, silver, or ion-selective membranes). It complies with ISO 8655-7 (volumetric equipment — titrators), ASTM E202–22 (standard test methods for titration), and supports GLP/GMP documentation requirements through its embedded event log (user login/logout, method load, titration start/end, calibration events). All data files are stored in vendor-neutral CSV format with embedded metadata (date/time, operator ID, method version), facilitating integration into LIMS or electronic lab notebook (ELN) platforms. The instrument architecture meets IEC 61010-1 safety standards for laboratory electrical equipment.

Software & Data Management

Data acquisition and method configuration are performed directly on-device via intuitive touch navigation — no PC dependency for routine operation. Raw titration curves (mV vs. volume), derivative plots, and final results are saved automatically with unique file naming (e.g., “COMA19_20240522_143247_Sample01.csv”). USB export enables post-acquisition analysis in Excel or third-party chemometrics tools. Optional PC software (sold separately) provides advanced features: batch report generation, statistical summary across replicates, custom formula definition for derived parameters (e.g., % acidity, mg CaCO₃/L), and FDA 21 CFR Part 11-compliant electronic signature modules with role-based access control and full audit trail.

Applications

• Pharmaceutical QC: assay of active ingredients (e.g., amine content in APIs via non-aqueous titration), chloride determination in saline solutions per USP & EP monographs.
• Food & Beverage: titratable acidity (TA) in wines and juices, salt content (NaCl) by argentometric titration, sulfur dioxide quantification in musts.
• Environmental Testing: alkalinity and hardness profiling in wastewater per APHA Standard Methods 2320 & 2340.
• Chemical Manufacturing: concentration verification of standardized NaOH/HCl/KSCN solutions, purity assessment of organic acids and bases.
• Academic Research: kinetic titration studies, stability constant determination, and multi-step titration sequence programming for complex equilibria.

FAQ

What electrode types are compatible with the COM-A19?
The instrument supports all standard BNC-terminated potentiometric electrodes, including combination pH electrodes, redox (Pt or Au), silver, fluoride, and calcium-selective electrodes — provided they operate within the ±2000 mV input range and exhibit stable offset voltage.
Can the COM-A19 perform back-titrations or multi-step titrations?
Yes — method programming allows up to 99 sequential steps, including pre-titration additions, pause intervals, conditional endpoints, and post-endpoint reagent dosing, enabling classical back-titrations and Karl Fischer moisture determinations when paired with appropriate reagents and electrodes.
Is the built-in thermal printer replaceable or serviceable onsite?
The printer module is field-replaceable using standard Torx tools; consumables (thermal paper rolls and print-head cleaning kits) are available as OEM spare parts with documented maintenance intervals.
Does the LAN interface support secure remote control or only monitoring?
The embedded web server supports read-only remote monitoring (live status, recent results, system logs); full method editing and titration initiation require local touchscreen authentication to maintain data integrity and regulatory compliance.
How is calibration traceability maintained for metrological audits?
Calibration records (date, standard used, slope/mV/decade, asymmetry potential) are stored in a protected internal database with immutable timestamps and linked to operator credentials — exportable as PDF or CSV for inclusion in quality system documentation.