METTLER TOLEDO ME104E Analytical Balance

Overview

The METTLER TOLEDO ME104E Analytical Balance is a high-precision, entry-level analytical instrument engineered for routine laboratory weighing tasks requiring traceable accuracy and long-term reliability. Operating on electromagnetic force compensation (EMFC) principle, the ME104E delivers stable, drift-resistant measurements under variable environmental conditions typical of QC labs, academic research settings, and pharmaceutical production support areas. With a maximum capacity of 110 g and readability of 0.1 mg (0.0001 g), it meets the performance requirements for applications governed by USP , ASTM E899, and ISO 9001 quality management systems. Its robust metal frame, reinforced housing, and overload protection up to 100 kg ensure mechanical integrity across years of daily use—making it suitable for environments where durability and consistent metrological performance are non-negotiable.

Key Features

• Electromagnetic force compensation sensor with 2-second stabilization time for rapid, repeatable results
• External calibration capability with user-accessible calibration weights (GWP®-recommended weights: 100.0 g and 5.0 g)
• Ergonomic design including front-adjustable leveling feet and smooth, rounded edges for effortless cleaning and contamination control
• ISO/GLP-compliant data handling: automatic date/time stamping on all printouts and RS232 output
• 10 built-in application modes—including formulation weighing, piece counting, density determination, percentage weighing, checkweighing, statistical analysis, and free-factor calculation
• OIML Class I legal-for-trade certification, supporting regulated weighing in manufacturing and distribution contexts subject to national metrology authority oversight
• Robust mechanical architecture with reinforced chassis and integrated overloading protection (up to 100 kg)

Sample Compatibility & Compliance

The ME104E accommodates standard laboratory samples ranging from powders and granules to small solid components and pre-weighed vials. Its 90 mm stainless steel weighing pan provides sufficient surface area for most analytical containers while maintaining optimal air-draft stability. The balance complies with international regulatory frameworks essential for GxP environments: full traceability via timestamped records satisfies FDA 21 CFR Part 11 audit trail expectations when paired with compliant data acquisition software; its linearity error of ±0.0002 g and repeatability ≤0.0001 g align with ISO/IEC 17025 calibration verification criteria; and its OIML Class I designation ensures metrological validity for commercial transactions or internal process controls requiring legal metrology assurance.

Software & Data Management

Data export is facilitated through a standard RS232 interface compatible with METTLER TOLEDO’s LabX® Lite software (optional), third-party LIMS platforms, and custom-built laboratory information systems. All weight values are transmitted with embedded metadata—including operator ID (if configured), timestamp, balance ID, and application mode—enabling full chain-of-custody documentation. Internal memory retains no raw data; instead, real-time transmission ensures immediate archival and eliminates post-measurement manual transcription errors. For laboratories operating under GLP or GMP, the ME104E supports electronic record integrity through deterministic output formatting and configurable report headers that include instrument serial number, calibration status, and environmental condition flags (e.g., draft detection alerts).

Applications

• Pharmaceutical formulation and active ingredient dispensing in R&D and pilot-scale production
• Raw material identity verification and assay sample preparation per USP monographs
• Quality control testing of excipients, tablets, and capsules using checkweighing and statistical process control
• Density determination of solids and liquids using the built-in density application module
• Academic teaching labs requiring durable, intuitive instruments for undergraduate chemistry and materials science coursework
• Environmental testing labs performing gravimetric analysis of filter residues or particulate matter
• Food safety laboratories conducting moisture content and ash residue quantification

FAQ

What is the difference between the ME104 and ME104E models?
The “E” suffix denotes external calibration capability only; the base ME104 includes internal calibration. Both share identical readability, repeatability, and mechanical specifications.
Is the ME104E compliant with FDA 21 CFR Part 11?
The balance itself does not store electronic signatures or enforce user authentication; however, when integrated with validated software (e.g., LabX®) and proper procedural controls, it supports Part 11 compliance for electronic records and signatures.
Can this balance be used for density measurement?
Yes—the ME104E includes a dedicated density determination application that calculates sample density using Archimedes’ principle with optional density kit accessories.
Does the ME104E support connectivity to modern LIMS systems?
Yes—via RS232 serial output with ASCII protocol, enabling seamless integration into legacy and contemporary laboratory informatics infrastructures.
What maintenance is required to sustain metrological performance?
Daily verification with certified check weights, periodic external calibration per ISO/IEC 17025 schedule, and routine cleaning of the weighing chamber and pan using lint-free, non-abrasive cloths are recommended.