Savillex ICP-MS PFA Inert Sample Introduction Kit for PerkinElmer NexION 300 Series

Overview

The Savillex ICP-MS PFA Inert Sample Introduction Kit (Model 850-011-100787) is a rigorously engineered consumable assembly designed to maximize analytical integrity in high-sensitivity inductively coupled plasma mass spectrometry (ICP-MS) applications. Built entirely from perfluoroalkoxy alkane (PFA), this kit eliminates metal leaching, adsorption, and memory effects commonly observed with quartz or polyether ether ketone (PEEK) components—particularly critical when quantifying ultra-trace elements (sub-femtogram levels) in aggressive matrices containing hydrofluoric acid (HF), concentrated nitric acid (HNO₃), or high total dissolved solids (TDS). Its dual-channel architecture enables simultaneous nebulizer gas and auxiliary make-up gas delivery, stabilizing plasma loading and improving signal-to-noise ratio during analysis of complex environmental, geological, semiconductor, and nuclear samples. The kit is fully compatible with PerkinElmer NexION 300-series ICP-MS systems and integrates seamlessly with Savillex’s C-Flow and X-Flow PFA nebulizers—both optimized for low uptake rate (≤ 50 µL/min) and high transport efficiency (> 40%). All components undergo pre-cleaning in trace-metal-grade HNO₃/HF solutions under Class 10 cleanroom conditions and are certified for ≤ 1 pg/mL blank contribution for key isotopes including Be, Al, Fe, Cu, Zn, and Pb.

Key Features

• Full PFA construction ensures exceptional chemical inertness against HF, hot HNO₃, aqua regia, and alkaline digestates—enabling direct analysis of digested silicate, borosilicate, and refractory oxide materials.
• Modular O-ring-sealed detachable end cap facilitates rapid cleaning, inspection, and replacement without disassembling the entire spray chamber interface.
• Dual-gas inlet design (nebulizer gas + optional makeup gas) supports stable plasma operation under variable sample viscosity and TDS loadings up to 25% w/v.
• 6 mm outer diameter (OD) nebulizer port accommodates all standard Savillex PFA nebulizers—including C-Flow (for routine ultra-trace analysis) and X-Flow (for high-TDS, high-salt, or suspended-particle-laden samples).
• Integrated drain connector enables gravity-assisted waste removal with minimal backpressure, reducing droplet coalescence and improving washout kinetics (< 30 s for 99% rinse recovery).
• Pre-cleaned and certified for compliance with ISO/IEC 17025:2017 method validation requirements; lot-specific Certificate of Analysis (CoA) provided with each kit.

Sample Compatibility & Compliance

This kit is validated for use with aqueous, organic, and mixed-phase samples across regulated and research environments. It supports EPA Method 6020B, ASTM D5673, ISO 17294-2, and USP / elemental impurities testing protocols. The PFA material meets USP Class VI biocompatibility standards and complies with FDA 21 CFR Part 11 data integrity requirements when paired with PerkinElmer Syngistix software. All components are manufactured in an ISO 9001-certified facility in Minnesota, USA, and conform to RoHS Directive 2011/65/EU and REACH Regulation (EC) No. 1907/2006. Trace metal background testing follows NIST SRM 3100 series verification practices.

Software & Data Management

While hardware-based, the kit enhances data fidelity for Syngistix for ICP-MS v5.3+ and earlier versions supporting NexION 300-series instrument control. Its consistent geometry and thermal stability reduce inter-run drift, enabling reliable long-term calibration maintenance (≤ 2% RSD over 12-h runs). Audit trails generated via Syngistix include component lot numbers, installation timestamps, and usage logs—supporting GLP/GMP-compliant workflows. Raw signal stability directly improves internal standard correction accuracy (e.g., using ¹¹⁵In or ¹⁸⁷Re), facilitating robust isotope ratio measurements required in geochemical fingerprinting and nuclear forensics.

Applications

• Ultra-trace multi-element analysis in seawater, groundwater, and wastewater per EPA 1638 and ISO 17294-2.
• High-purity acid certification (e.g., UP-S, SE-U grade HNO₃, HF, HCl) for semiconductor manufacturing.
• Dissolved/particulate fractionation studies in marine biogeochemistry using offline filtration and PFA-based dialysis cells.
• Direct analysis of HF-digested geological reference materials (e.g., BCR-2, AGV-2, BHVO-2) without post-digestion dilution.
• Radioisotope quantification (e.g., ²³⁶U/²³⁸U, ¹²⁹I) in environmental monitoring where reagent blanks dominate detection limits.

FAQ

Is this kit compatible with NexION 300D, 300S, and 350D models?
Yes—mechanical and pneumatic interfaces are identical across all NexION 300-series platforms.
Can I use non-Savillex PFA nebulizers with this kit?
Only if they feature a 6 mm OD body and comply with Savillex’s torque specification (0.3–0.5 N·m); however, performance validation is the user’s responsibility.
Does the kit include the spray chamber?
No—the kit contains only the inert introduction assembly (end cap, drain connector, and nebulizer mounting interface); the spray chamber must be ordered separately.
How often should the O-rings be replaced?
Under normal operation (≤ 8 h/day, 5 days/week), replace O-rings every 6 months or after 200 acid-clean cycles—whichever occurs first.
Are replacement parts available individually?
Yes: end caps (P/N 850-011-100786), drain connectors (P/N 850-011-100788), and O-ring kits (P/N 850-011-100789) are stocked and ship within 24 h from US distribution centers.