Shimadzu LC-2010CHT Integrated HPLC System (Refurbished)
| Brand | Shimadzu |
|---|---|
| Origin | Japan |
| Model | LC-2010CHT |
| Pump | Serial dual-plunger micro-pump (10 µL primary, 5 µL secondary) |
| Flow rate range | 0.001–5.0 mL/min (at 1.0–35.0 MPa) |
| Flow precision | ≤0.075% RSD (0.05–2.0 mL/min, methanol, 20 °C) |
| Low-pressure gradient elution | Up to 4 solvents, 0.1% increment |
| Autosampler injection volume | 0.1–100 µL |
| Injection repeatability | ≤0.3% RSD (10 µL) |
| Column oven temp. range | (ambient −15) to 60 °C, stability ±0.1 °C |
| UV-Vis detector | Deuterium lamp, 190–600 nm, wavelength accuracy ±1 nm, wavelength reproducibility ±0.1 nm, drift ≤1×10⁻⁴ AU/h (250 nm), S/N ≥0.25×10⁻⁵ AU (1 s response, air cell) |
| Dimensions (W×D×H) | 430 × 500 × 605 mm |
| Weight | 52 kg |
Overview
The Shimadzu LC-2010CHT Integrated HPLC System is a factory-refurbished, fully functional high-performance liquid chromatograph engineered for robust routine analysis in regulated and research environments. Designed as a single-chassis integrated platform, it incorporates all core HPLC modules—including a low-pressure gradient solvent delivery system, high-precision serial dual-plunger pump, fast autosampler with variable-volume injection, thermostatically controlled column oven, and a high-stability UV-Vis absorbance detector—within a compact footprint (430 × 500 × 605 mm). Its architecture follows Shimadzu’s proven CHT (Compact, High-throughput, Temperature-controlled) design philosophy, emphasizing mechanical rigidity, thermal equilibrium, and minimized dwell volume to ensure retention time reproducibility and peak shape fidelity across extended operation cycles. The system operates on standard laboratory AC power (100–240 V), requiring no external chillers or auxiliary gas supplies, making it suitable for deployment in QC labs, academic core facilities, and contract testing laboratories where space, reliability, and operational continuity are critical constraints.
Key Features
- Integrated low-pressure gradient unit supporting up to four mobile phases with 0.1% composition resolution, enabling method flexibility without hardware reconfiguration.
- Dual-stage micro-plunger pump delivering flow rates from 0.001 to 5.0 mL/min at pressures up to 35.0 MPa, with flow precision validated per ISO 11843-7 and ASTM D7217 protocols (≤0.075% RSD under specified conditions).
- Autosampler featuring needle-in-loop injection mode, eliminating sample carryover; injection volume programmable from 0.1 to 100 µL with ≤0.3% RSD repeatability at 10 µL.
- Column oven with active pre-heating of mobile phase and Peltier-based heating/cooling, maintaining temperature stability within ±0.1 °C across the full operating range (ambient −15 °C to 60 °C).
- UV-Vis detector equipped with a deuterium lamp source, spectral range 190–600 nm, fixed 8 nm bandwidth, and real-time wavelength calibration traceable to NIST-standard reference materials.
- Refurbishment includes full mechanical inspection, pump seal replacement, detector lamp validation, solvent path cleaning and pressure leak testing, plus firmware verification against Shimadzu’s original release baseline (v2.3x series).
Sample Compatibility & Compliance
The LC-2010CHT accommodates standard 3.0–4.6 mm ID analytical columns (up to 250 mm length) and is compatible with reversed-phase (C18, C8), HILIC, ion-exchange, and size-exclusion chemistries. It supports aqueous-organic mobile phases (e.g., water/acetonitrile, water/methanol) and common buffers (e.g., phosphate, acetate, ammonium formate) within pH 2–8. All fluidic components are chemically resistant stainless steel or PEEK-lined. The system meets mechanical and electrical safety requirements per IEC 61010-1:2010 and carries CE marking. While not supplied with 21 CFR Part 11-compliant software by default, its native ClassManager™ v2.x data acquisition engine supports audit trail logging, user access levels, and electronic signature configuration when deployed with validated IT infrastructure and procedural controls aligned with GLP/GMP practices.
Software & Data Management
Data acquisition and instrument control are managed via Shimadzu’s ClassManager™ software (v2.35 or later), installed on a dedicated Windows-based workstation included with the system. ClassManager provides sequence-based batch processing, real-time chromatogram display, peak integration using EMG or Gaussian models, and customizable report templates compliant with ISO/IEC 17025 reporting clauses. Raw data (.lcd files) are stored in vendor-neutral formats with embedded metadata (method parameters, instrument logs, calibration history). System-generated audit trails record user actions, method changes, and data modifications with timestamps and operator IDs—configurable for regulatory review. Backup and archiving follow NIST SP 800-88 guidelines; raw data retention policies may be enforced via scheduled export to network-attached storage or LTO tape media.
Applications
This refurbished LC-2010CHT is routinely deployed in pharmaceutical QC for assay and related substances testing (per USP and EP 2.2.46), food safety labs for pesticide residue screening (AOAC 2007.01), environmental monitoring for PAHs and phenols (EPA Method 8330B), and natural product labs for flavonoid and alkaloid profiling. Its thermal stability and gradient reproducibility support method transfer from development to routine use, while the low dwell volume (<1.2 mL) ensures compatibility with narrow-bore and UHPLC-compatible columns when operated below 2.0 mL/min. The system has demonstrated long-term performance in multi-year stability-indicating assays, with column backpressure drift <2% over 2,000 injections under typical C18 conditions.
FAQ
Is this unit covered by Shimadzu’s original manufacturer warranty?
No. As a refurbished instrument sourced through an authorized Shimadzu distributor channel, it carries a 12-month limited parts-and-labor warranty administered by the supplying dealer—not Shimadzu Corporation.
Can this system be upgraded to support modern networked LIMS integration?
Yes. ClassManager™ supports ODBC-compliant database export and HL7 messaging via optional middleware. Integration with LabVantage, Thermo SampleManager, or Waters Empower requires third-party interface validation per your lab’s change control SOP.
What documentation is provided with the refurbished unit?
A full refurbishment report, post-calibration certificate (pump flow, detector wavelength/S/N), electrical safety test record, and signed statement of conformance to Shimadzu’s refurbished equipment standards (REF-STD-2022 Rev. B) are included.
Is installation and qualification support available?
Yes. IQ/OQ protocols aligned with ASTM E2500-13 and EU Annex 15 are available for purchase; on-site commissioning and operational qualification assistance can be arranged through certified field engineers.
Are consumables and spare parts still available?
All major subassemblies (pump heads, autosampler valves, detector flow cells) and consumables (seals, frits, lamps) remain in active production or are available from Shimadzu’s global spares distribution network through Q3 2027.
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