Thermo Scientific Dionex AS-AP Automated Sample Processor
| Brand | Thermo Fisher |
|---|---|
| Origin | Canada |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | AS-AP |
| Price Range | USD 6,800 – 13,600 (FOB) |
| Product Category | Chromatography |
| Service Life | 4–5 years |
| Warranty | 6 months |
Overview
The Thermo Scientific Dionex AS-AP Automated Sample Processor is a high-precision, modular autosampler engineered for ion chromatography (IC) and liquid chromatography (LC) workflows requiring robust automation, trace-level reproducibility, and method flexibility. Based on the proven PEEK™ fluidic architecture and syringe-driven sampling principle, the AS-AP implements precise positive-displacement metering to deliver sub-microliter accuracy across diverse sample matrices—including aqueous environmental extracts, biological fluids, food digests, and industrial process streams. Its core design adheres to the fundamental requirements of quantitative IC analysis: minimal carryover (<0.01%), low dead-volume flow paths, and inert wetted materials (entirely PEEK™ and ceramic components), ensuring compatibility with aggressive eluents (e.g., KOH, methanesulfonic acid) and preserving analyte integrity during extended unattended operation.
Key Features
- Sub-0.3% relative standard deviation (RSD) for repeated injections—validated per ASTM D7984 and ISO 11843-2 for precision-critical quantitation
- Modular needle motion system enabling reliable aspiration from 10 mL vials (up to 81 samples), 96-well and 384-well microplates (up to 1152 samples), and custom tube racks
- Full PEEK™/ceramic fluidic path—including syringe, needle, valve rotor, and transfer lines—eliminating metal leaching and corrosion in high-pH or acidic eluent environments
- Programmable sample tray temperature control (4–60°C) with active cooling/heating and real-time monitoring, compliant with ICH Q5C stability testing guidelines
- Parallel or sequential injection capability for dual-IC system integration—prevents reagent cross-contamination and supports synchronized method development
- Integrated pre-injection analytics: automated conductivity and pH measurement prior to injection, reducing manual QC steps and enabling real-time matrix assessment
- On-board fraction collection, auto-dilution, re-injection, and column pre-derivatization support—enabling multi-step sample preparation without external hardware
Sample Compatibility & Compliance
The AS-AP accommodates a broad range of sample containers and volumes—from 0.3 mL microvials to 100 mL reservoir bottles—and interfaces seamlessly with Thermo Scientific Dionex ICS-5000+, ICS-6000, and legacy ICS-2100 systems via standard RS-232 and Ethernet protocols. All firmware and hardware configurations meet essential regulatory expectations for GLP/GMP environments: audit-trail-enabled software logging (per FDA 21 CFR Part 11), electronic signature support, and full traceability of injection sequence, temperature setpoints, and maintenance events. The system has been verified for compliance with USP , ISO 17025:2017 (Clause 5.9), and ASTM D4327 for anion/cation analysis in drinking water and wastewater applications.
Software & Data Management
Controlled via Chromeleon™ CDS (version 7.3 or later), the AS-AP integrates into centralized instrument networks with full remote scheduling, method inheritance, and event-driven triggering. Chromatographic data files include embedded metadata (sample ID, tray position, temperature log, syringe actuation count), supporting automated report generation and LIMS interfacing (via ODBC or REST API). Firmware updates preserve backward compatibility with legacy methods, and calibration logs are retained for ≥12 months—satisfying internal QA retention policies and external inspection requirements.
Applications
The AS-AP is routinely deployed in environmental laboratories for EPA Method 300.0/300.1 anion analysis; in pharmaceutical QC for residual counterion profiling (e.g., Na⁺, Cl⁻, acetate); in food safety labs for nitrate/nitrite quantification per AOAC 997.03; and in semiconductor manufacturing for ultra-trace chloride and fluoride monitoring in ultrapure water (UPW). Its automated matrix elimination and pre-concentration modules enable direct injection of complex samples such as soil leachates and cell culture supernatants—reducing manual pretreatment time by >70% versus manual protocols.
FAQ
Is this unit certified for use in regulated GxP environments?
Yes—the AS-AP’s firmware, audit trail functionality, and electronic signature support comply with FDA 21 CFR Part 11 and EU Annex 11 when operated within a validated Chromeleon CDS environment.
What maintenance history is available for this used unit?
This unit underwent full functional verification at SpectraLab Scientific’s ISO/IEC 17025-accredited service lab, including syringe calibration, carryover testing, temperature uniformity mapping, and valve leak detection—all documented in the included Certificate of Performance.
Can the AS-AP be retrofitted with newer firmware or accessories?
Yes—hardware revision E and later support all current Dionex AS-AP firmware versions and optional modules (e.g., AutoPrep™, Fraction Collector FC-100), subject to physical interface compatibility.
Does the 6-month warranty cover parts, labor, and on-site service?
The warranty covers parts and labor for defects in materials or workmanship; remote diagnostics and firmware support are included; on-site service is available at additional cost under separate service agreement terms.
