METTLER TOLEDO EasyPlus iTitrate™ Automatic Potentiometric Titrator
| Brand | METTLER TOLEDO |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Status | Authorized Distributor |
| Product Origin | Domestic (China) |
| Models | ET18 / ET28 / ET38 / ET58 / Easy Na |
| Instrument Type | General-purpose Potentiometric Titrator |
| Application Scope | Universal |
| Measurement Ranges | pH: 1–14 |
| mV | 0–2000 mV |
| Temperature | 0–100 °C |
| Meter Accuracy | ±0.2% of full scale |
| Meter Resolution | pH: 0.01 pH |
| mV | 0.1 mV |
| Temperature | 0.1 °C |
| Titration Stability | (±0.3 mV ±1 digit) over 3 h |
Overview
The METTLER TOLEDO EasyPlus iTitrate™ Automatic Potentiometric Titrator is a compact, benchtop electrochemical analyzer engineered for precision and reproducibility in routine potentiometric titrations. Based on the fundamental principle of measuring potential difference between a reference electrode and an indicator electrode as titrant is incrementally added, the system detects inflection points in the E–V (potential vs. volume) curve to determine end points with high resolution. Designed and validated by METTLER TOLEDO’s Swiss R&D center, the EasyPlus platform adheres to international design standards for analytical instrumentation—including mechanical robustness, electromagnetic compatibility (EMC), and thermal stability across laboratory environments (15–30 °C, 30–80% RH non-condensing). Its architecture supports GLP-compliant workflows through built-in audit trail capabilities, user access levels, and method versioning—ensuring traceability required under ISO/IEC 17025, USP , and FDA 21 CFR Part 11 when configured with appropriate software modules.
Key Features
- iTitrate™ intuitive touchscreen interface—designed with smartphone-like icon navigation, LongClick™ shortcut activation for recently used methods, and responsive haptic feedback for tactile confirmation.
- Multi-language support (15 languages including English, German, French, Spanish, Japanese, and Chinese) embedded at firmware level—no external localization packages required.
- Pre-validated method templates for acid-base, redox, precipitation, and Karl Fischer volumetric water determination—reducing method development time by up to 70% compared to manual setup.
- Integrated EasySetup™ wizard guides users step-by-step through electrode selection, titrant concentration input, equivalence point detection algorithm (e.g., first derivative, second derivative, or fixed ΔE/ΔV), and unit conversion—minimizing parameter misconfiguration.
- Modular hardware design: interchangeable burettes (10 mL, 20 mL, 50 mL), motorized dosing units with anti-drip valves, and auto-calibrating temperature sensor (Pt1000) ensure consistent delivery accuracy and thermal compensation during extended runs.
- Real-time titration curve visualization with overlay capability for comparative analysis; data export in CSV, PDF, and XML formats compliant with LIMS integration protocols.
Sample Compatibility & Compliance
The EasyPlus series accommodates liquid and semi-liquid samples across food & beverage (e.g., fruit juice acidity, beer titratable acidity, wine SO₂), pharmaceutical excipients (e.g., sodium chloride content in saline solutions), environmental water matrices (Cl⁻ in drinking water per ISO 9297), and industrial chemicals (peroxide value in oils per AOAC 965.33). All standard configurations include glass pH electrodes, Ag/AgCl redox electrodes, silver nitrate-compatible precipitation electrodes, and dual-platinum Karl Fischer electrodes. Instruments comply with IEC 61010-1 for electrical safety, CE marking for EMC and low-voltage directives, and meet the essential requirements of ISO 8655-3 (burette accuracy) and ISO 7027 (electrode calibration traceability). Optional accessories enable compliance with pharmacopeial monographs (USP , EP 2.2.20) via certified reference materials and documented IQ/OQ protocols.
Software & Data Management
Data integrity is maintained through firmware-level security controls: password-protected user roles (Operator, Supervisor, Administrator), electronic signatures for critical actions (method validation, result approval), and immutable audit trails recording timestamp, user ID, parameter changes, and raw sensor output. The iTitrate™ software supports automated report generation with customizable headers, footers, and regulatory metadata (e.g., instrument ID, electrode serial number, calibration history). When connected to METTLER TOLEDO LabX™ software (optional), the system enables centralized method deployment, remote monitoring, electronic lab notebook (ELN) synchronization, and full 21 CFR Part 11 compliance—including digital signature validation and long-term archival in tamper-evident format.
Applications
- Acid–base titrations: Total acidity in dairy products (titratable acidity to phenolphthalein endpoint, “p-value”), citric acid in soft drinks, free fatty acids in edible oils (AOAC 940.28).
- Redox titrations: Ascorbic acid (vitamin C) in fortified beverages (AOAC 967.21), sulfur dioxide in wine (AOAC 990.28), peroxide value in rancidity assessment (ISO 3960).
- Precipitation titrations: Chloride quantification in foodstuffs (ISO 9297), salt content in processed meats, silver ion concentration in plating baths.
- Karl Fischer titrations: Volumetric water determination in solvents (e.g., methanol, acetone), hygroscopic APIs (ICH Q5C), and polymer pellets (ASTM D6304).
FAQ
What electrode types are supported out-of-the-box?
The EasyPlus series ships with standardized BNC-compatible electrodes: a combined pH electrode (InLab® Expert Pro), a Pt redox electrode, a Ag titration electrode for Cl⁻, and dual-platinum KF electrodes. All are pre-characterized and auto-recognized by the system.
Can the instrument perform back-titrations or multi-step titrations?
Yes—via programmable method sequences supporting up to 5 sequential titration steps, conditional branching based on intermediate results, and automatic reagent switching using optional multi-burette modules.
Is method validation documentation available?
METTLER TOLEDO provides IQ/OQ documentation templates, performance verification checklists (e.g., repeatability of 0.1 mL additions, pH electrode response time), and traceable calibration certificates for all shipped electrodes and burettes.
How is data backup handled?
Internal 8 GB flash memory stores ≥10,000 titration reports with raw curves; USB export supports encrypted backups; LabX connectivity enables scheduled cloud or network drive synchronization.
Does the system support external pH meters or third-party electrodes?
Only METTLER TOLEDO-certified electrodes are fully supported for automatic calibration, diagnostics, and temperature compensation. Non-certified electrodes may connect via BNC but lack firmware-level validation and error correction algorithms.
