MD200-1 Nitrogen Evaporator

Overview

The MD200-1 Nitrogen Evaporator is an engineered solution for parallel, inert-atmosphere solvent removal in analytical and preparative laboratories. It operates on the principle of controlled nitrogen gas flow directed tangentially across the surface of heated liquid samples—accelerating evaporation while minimizing oxidation, thermal degradation, or analyte loss. Unlike rotary evaporation—which requires vacuum infrastructure, individual flask handling, and extended cycle times—the MD200-1 enables simultaneous concentration of up to 49 samples (depending on selected module), significantly improving throughput in high-volume workflows such as clinical toxicology screening, pharmaceutical stability testing, environmental residue analysis, and metabolomics sample preparation. Its modular architecture supports method standardization across diverse vessel formats without hardware replacement, making it suitable for regulated environments where traceability, reproducibility, and operator safety are critical.

Key Features

• Independent gas needle control per position—enables selective activation to conserve nitrogen and reduce operational cost
• Adjustable gas manifold height and needle positioning—ensures optimal gas impingement distance over varying solvent levels, including low-volume microcentrifuge tubes
• Single-zone heating block with ±0.5°C accuracy between 40–100°C and rapid thermal response (≤30 min to reach 150°C from 40°C)
• Integrated digital timer with countdown display and auto-shutdown—supports unattended operation up to 99 hours 59 minutes
• Real-time temperature monitoring with 0.1°C resolution and LED interface—provides immediate feedback for process validation
• Over-temperature cut-off and self-diagnostic system with audible alert—meets IEC 61010-1 safety requirements for laboratory equipment
• Compact footprint (280 × 240 × 500 mm) and optional fume hood compatibility—ideal for space-constrained QC labs and shared instrumentation suites

Sample Compatibility & Compliance

The MD200-1 accepts 18 interchangeable aluminum heating blocks (BK01–BK18), accommodating tube diameters from 0.5 mL microcentrifuge vials to 40 mm wide culture tubes. Each block maintains uniform thermal distribution across all wells, verified per ASTM E220–22 calibration guidelines. The system supports Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) workflows through deterministic parameter logging (when paired with optional data export modules) and adherence to USP Analytical Instrument Qualification principles. While the base unit does not include 21 CFR Part 11-compliant audit trail functionality, its analog control architecture allows integration into validated networks via external PLC or SCADA interfaces when deployed in regulated pharmaceutical or clinical diagnostics settings.

Software & Data Management

The MD200-1 operates via embedded firmware with no proprietary software dependency—ensuring long-term maintainability and eliminating license renewal risks. All setpoints (temperature, time) are stored in non-volatile memory and persist after power cycling. For laboratories requiring electronic record retention, optional RS-232 or USB-to-serial adapters enable connection to LIMS or ELN platforms using ASCII-based command protocols. Temperature profiles can be logged externally at user-defined intervals (e.g., every 30 seconds), supporting IQ/OQ documentation per ISO/IEC 17025 Clause 6.4.2. No cloud connectivity or remote access capabilities are included—consistent with cybersecurity best practices for instrument-controlled environments.

Applications

• Pre-concentration of extracts prior to GC-MS or LC-MS/MS analysis in food safety and environmental testing (e.g., pesticide multiresidue methods AOAC 2007.01, EPA 8270)
• Routine cleanup of plasma, urine, or tissue homogenates in clinical endocrinology and therapeutic drug monitoring
• High-throughput sample drying in genotoxic impurity studies compliant with ICH M7(R2)
• Stabilization of light- or oxygen-sensitive compounds—including retinoids, prostaglandins, and certain oligonucleotides—during biobank processing
• Parallel evaporation of reaction mixtures in medicinal chemistry synthesis support labs

FAQ

Is the MD200-1 compatible with corrosive solvents such as chloroform or DCM?
Yes—provided the instrument is operated inside a certified fume hood and the gas needles are periodically inspected for erosion. Aluminum blocks are anodized to resist mild organic solvents; prolonged exposure to strong acids or halogenated solvents may require optional stainless-steel needle upgrades.
Can multiple MD200-1 units be synchronized for batch processing?
No native synchronization protocol exists; however, identical setpoints can be replicated manually across units. For coordinated timing, external programmable timers or building management systems may trigger power relays.
What maintenance is required to ensure long-term temperature accuracy?
Annual verification using a NIST-traceable PT100 probe is recommended. Cleaning of gas channels with ethanol and lint-free swabs every 200 operating hours prevents particulate buildup that affects flow uniformity.
Does the system support external nitrogen supply pressure regulation?
Yes—the inlet accepts regulated input up to 0.1 MPa. An optional inline precision flow control valve (sold separately) enables fine-tuning per needle for heterogeneous sample matrices.
Are calibration certificates provided with shipment?
A factory calibration report (including temperature deviation at three points: 40°C, 80°C, and 120°C) is included. Full UKAS or DAkkS-accredited calibration requires third-party service engagement.