Thermo Scientific Nanopure Life Science Series Ultra-Pure Water System
| Brand | Thermo Fisher |
|---|---|
| Origin | USA |
| Manufacturer | Thermo Fisher Scientific |
| Product Category | Imported |
| Model | Nanopure Life Science Series |
| Pricing | Available Upon Request |
| Resistivity | 18.2 MΩ·cm @ 25 °C |
| TOC | 1–5 ppb |
| Endotoxin | <0.001 EU/mL |
| Bacterial Count | <1 CFU/mL |
| Particles (>0.2 µm) | <1 /mL |
| Silica | <1 ppb |
| UV Absorbance @ 254 nm | <0.001 AU |
| Flow Rate | 1.8 L/min |
| Feed Water Requirements | Pre-treated RO, distilled or deionized water |
| Pressure | 100 psi (6.9 bar) |
| Temperature | 4–40 °C |
| Intelligent Dispensing Range | 0.25–60 L |
| Accuracy | ±5% (≥1 L), Repeatability: ±3% |
| Conductivity Cell Constant | 0.1 cm⁻¹ |
| Temp. Sensor Accuracy | ±0.1 °C |
| Dimensions (W×H×D) | 34.3 × 49.5 × 43.2 cm |
| Installation | Benchtop or wall-mounted (included bracket) |
| Service Clearance | Side >22.9 cm, Top >7.6 cm, Front >12.1 cm |
| Power | 90–240 VAC, 100 VA, 47–63 Hz, Single Phase |
| Tubing | Feed line Ø11.43 mm (supplied), Drain line Ø7.62 mm (supplied) |
Overview
The Thermo Scientific Nanopure Life Science Series is a high-performance ultra-pure water system engineered specifically for demanding life science applications—including cell culture, molecular biology, qPCR, next-generation sequencing (NGS), monoclonal antibody production, and stem cell research. It employs a multi-stage purification architecture integrating dual-wavelength UV oxidation (185/254 nm), high-capacity ion exchange resins, ultrafiltration (UF), and a 0.2 µm sterile-grade hollow-fiber final filter to consistently deliver Type I+ ultrapure water meeting or exceeding ASTM D1193-20, ISO 3696:1987, and CLSI EP21-A standards. The system’s core design principle centers on minimizing bioburden, endotoxin, nucleases, and organic contaminants—critical parameters for sensitive biological assays where trace impurities can compromise reproducibility, enzymatic activity, or cell viability.
Key Features
- Dual-Wavelength UV Oxidation: Simultaneous 185 nm (for organic photolysis) and 254 nm (for microbial inactivation) lamps ensure robust TOC reduction and microbial control without chemical sanitants.
- Endotoxin- and Nuclease-Specific Purification: Integrated ultrafiltration module with certified low-endotoxin (<0.001 EU/mL) and nuclease-free (<0.01 pg/µL DNase/RNase) performance—validated per USP and , and supported by manufacturer-issued water quality white papers.
- Real-Time TOC Monitoring (D11971 model): On-line total organic carbon analyzer with <5 ppb detection limit and automatic calibration verification—essential for GLP/GMP-regulated labs requiring continuous water quality assurance.
- Intelligent Dispensing Interface: Touchscreen-enabled quantitative delivery (0.25–60 L), programmable timed dispensing (1–40 min intervals), and ±3% volumetric repeatability—compatible with lab automation via optional RS232/USB outputs.
- Modular Durapack Cartridge System: Pre-assembled, factory-validated purification packs—including reverse osmosis pretreatment (D50280), deionization (D50281), and UV/UF modules—minimize installation error and reduce service downtime.
- Remote Display & Sanitization Protocol: Detachable control panel (up to 3 m cable length) enables ergonomic placement; automated chemical-free recirculation sanitization cycle ensures compliance with FDA 21 CFR Part 11 audit trails when paired with optional software logging.
Sample Compatibility & Compliance
The Nanopure Life Science Series is validated for compatibility with critical life science workflows requiring stringent water purity: mammalian and insect cell culture media preparation, electrophysiology buffer formulation, HPLC mobile phase generation, and CRISPR/Cas9 reagent dilution. All models comply with ISO/IEC 17025-accredited third-party verification protocols conducted at independent U.S. laboratories. System output meets or exceeds the specifications outlined in ASTM D1193-20 (Type I), CLSI EP21-A (for analytical use), and ISO 13485 Annex A (for medical device manufacturing support). Optional IQ/OQ documentation packages are available to support 21 CFR Part 11 and EU Annex 11 validation requirements.
Software & Data Management
While the base system operates via embedded firmware with local data logging (resistivity, TOC, temperature, flow volume, and alarm history), optional Thermo Scientific H2O SELECT Connect software enables centralized fleet monitoring across multiple instruments. This secure, browser-based platform supports role-based access control, electronic signatures, and automated report generation compliant with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). All system events—including cartridge replacement alerts, UV lamp life tracking, and sanitization logs—are timestamped and stored with immutable audit trails for regulatory inspections.
Applications
- Molecular biology: DNA/RNA extraction, RT-qPCR, library prep for NGS, transfection reagent preparation
- Cell culture: Basal media formulation, serum-free supplement dilution, passaging buffers
- Protein biochemistry: HPLC gradient eluents, affinity chromatography wash buffers, enzyme assay diluents
- Regulatory testing: USP water quality testing, pharmacopeial method development, stability study preparations
- Diagnostic manufacturing: IVD reagent production, calibrator diluent preparation, cleanroom humidification feedwater
FAQ
What feed water quality is required for optimal Nanopure Life Science operation?
Pre-treated feed water must meet specified limits: TOC < 1 ppm, turbidity < 1.0 NTU, pressure 100 psi (6.9 bar), temperature 4–40 °C, TDS < 70 ppm (as CaCO₃), and SDI < 5%. RO, distillation, or DI pre-treatment is mandatory.
Is the system compatible with wall-mount installation?
Yes—standard configuration includes a UL-listed wall-mount bracket and all necessary hardware for secure vertical mounting; minimum clearance dimensions are provided in the technical manual.
How often must the Durapack cartridges be replaced?
Cartridge lifetime depends on feed water quality and daily usage volume; typical service intervals range from 6–12 months. The system provides real-time resin exhaustion indicators and integrated flow-meter-based usage tracking.
Does the Nanopure Life Science Series support 21 CFR Part 11 compliance?
With optional H2O SELECT Connect software and configured user authentication, electronic signatures, and audit trail archiving, the system satisfies core Part 11 requirements for electronic records and signatures in regulated environments.
Can the system be integrated into a building management system (BMS)?
Yes—via optional analog 4–20 mA or digital Modbus RTU outputs, enabling remote status monitoring (e.g., resistivity alarm, UV lamp failure, low flow) within facility-wide infrastructure networks.
