TKA GenPure UV-TOC/UF xCAD Ultra Pure Water System
| Origin | Imported |
|---|---|
| Manufacturer Type | Distributor |
| Model | GenPure UV-TOC/UF xCAD |
| Price | Upon Request |
| Feed Water | Distilled / RO / DI Water |
| Resistivity | 18.2 MΩ·cm @ 25 °C |
| Conductivity | 0.055 µS/cm @ 25 °C |
| TOC | 1–5 ppb |
| Endotoxin | ≤ 0.001 EU/mL |
| RNase | < 0.01 ng/mL |
| DNase | < 4 pg/µL |
| Microbial Count | ≤ 1 CFU/mL |
| Flow Rate | 0–2 L/min (continuously adjustable) |
| Dispense Volume Range | 0.01–65.0 L (programmable) |
| Real-time In-line TOC Monitoring | Yes (full-loop, non-sampling) |
| UV Lamp Intensity Monitoring | Dual-wavelength (185 nm & 254 nm) with real-time energy % display (UV intensity sensor, not timer-based) |
| Temperature Sensor Accuracy | ±0.1 °C |
| System-wide Wetted-Path Sanitization | Yes (including UF, storage loop, and distribution lines) |
| Remote Control | xCAD controller (up to 3 arms, 3 m max distance, 180° rotation, 0.8 m arm extension, max dispense flow 1.2 L/min) |
| Display | 4-line adjustable-angle LCD with auto-diagnostics, maintenance alerts, and alarms |
| Interface | RS232 for PC or dedicated printer connectivity |
| Standard Configuration | Main unit (integrated TOC analyzer, dual conductivity sensors, PT100 temperature probe, UV intensity sensor, UF module, dual-wavelength UV lamp), one integrated purification cartridge, terminal 0.22 µm filter |
Overview
The TKA GenPure UV-TOC/UF xCAD Ultra Pure Water System is an engineered solution for laboratories requiring continuous, on-demand production of Type I ultrapure water compliant with ASTM D1193-20, ISO 3696:1987, CLSI EP21-A, and USP (Total Organic Carbon) and (Conductivity) monographs. It employs a multi-stage purification architecture integrating reverse osmosis pre-treatment (feed water requirement: distilled, RO, or deionized), dual-wavelength ultraviolet photooxidation (185 nm for TOC mineralization, 254 nm for microbial inactivation), ultrafiltration (UF) for endotoxin and nucleases removal, and final polishing via a single integrated purification cartridge containing mixed-bed ion exchange and activated carbon media. Unlike conventional systems relying on time-based UV lamp replacement schedules, the GenPure xCAD utilizes a calibrated UV intensity sensor to monitor real-time irradiance output—ensuring consistent photolytic efficiency across lamp lifetime and eliminating uncertainty associated with aging, ambient temperature, or power fluctuations.
Key Features
- Real-time, full-loop in-line TOC monitoring: All product water passes through the TOC analyzer; no intermittent sampling or bypass loops—enabling true dynamic quality assurance.
- UV intensity–based lamp management: Industrial-grade UV radiometric sensor provides % energy output readout, replacing unreliable hour-count timers and supporting predictive maintenance per ISO/IEC 17025 calibration traceability.
- Comprehensive wetted-path sanitization: Automated thermal or chemical (e.g., hydrogen peroxide) protocol extends across the entire fluidic path—including UF membrane housing, recirculation loop, distribution tubing, and dispensing arms—mitigating biofilm formation risks inherent in high-resistivity water systems.
- xCAD remote dispensing platform: Supports up to three articulating arms (180° swivel, 0.8 m reach, 1.2 L/min max flow), synchronized with the main unit’s status and control logic via shielded RS485 communication (3 m max cable length).
- Integrated purification cartridge: Combines pre-deionization and final polishing into one replaceable module—reducing footprint, minimizing connection points, and enabling tool-free, front-access cartridge replacement in under 60 seconds.
- Regulatory-ready data integrity: RS232 interface supports GLP-compliant audit trails; timestamped conductivity, TOC, temperature, UV intensity, and alarm logs export directly to PC or thermal printer without third-party software.
Sample Compatibility & Compliance
The GenPure UV-TOC/UF xCAD delivers water meeting or exceeding specifications required for sensitive analytical and life science applications: LC-MS, ICP-MS, AAS, HPLC mobile phase preparation, cell culture media formulation, qPCR, CRISPR editing workflows, and ELISA substrate preparation. Its ≤0.001 EU/mL endotoxin level satisfies USP and EP 2.6.14 criteria for sterile pharmaceutical manufacturing support. RNase/DNase specifications (<0.01 ng/mL and <4 pg/µL respectively) align with recommendations in ISO/IEC 17025-accredited molecular biology labs. All electronic components—including conductivity cells, TOC oxidation chamber, and temperature probes—are calibrated per NIST-traceable procedures and documented in the system’s factory certificate of conformance.
Software & Data Management
No proprietary software is required for basic operation or data capture. The embedded firmware manages all sensor acquisition, alarm logic (e.g., TOC excursion >5 ppb, resistivity drop <18.0 MΩ·cm, UV intensity <70% nominal), and scheduled maintenance prompts. RS232 output transmits ASCII-formatted data streams compatible with LabArchives, Electronic Lab Notebooks (ELNs), and LIMS platforms supporting ASTM E1384 or HL7 messaging. Audit trail records include operator ID (if configured via external authentication), event type, timestamp (ISO 8601), and parameter values—fully compliant with FDA 21 CFR Part 11 requirements when paired with validated user access controls and electronic signature workflows.
Applications
This system serves as primary ultrapure water source in core facilities supporting proteomics (nano-LC-MS/MS), trace metal analysis (ICP-MS detection limits sub-fg/L), semiconductor wafer cleaning validation, and biopharmaceutical process development. Its stable 18.2 MΩ·cm output ensures minimal baseline drift during long-gradient HPLC runs; its low TOC and endotoxin levels prevent column fouling and false-positive immunoassays. The xCAD dispensing interface enables ergonomic, contamination-minimized water delivery at multiple bench locations—critical in high-throughput genomics labs where pipetting ergonomics impact technician fatigue and reproducibility.
FAQ
Does the system meet USP and requirements for TOC and conductivity verification?
Yes—the integrated TOC analyzer is validated per USP , and dual conductivity sensors are certified to ±0.01 µS/cm accuracy at 25 °C, satisfying USP instrumentation criteria.
How is UV lamp performance verified without a timer-based replacement schedule?
The system uses a NIST-traceable UV-C radiometer (254 nm) mounted adjacent to the lamp chamber, reporting real-time irradiance as a percentage of initial output—triggering service alerts when intensity falls below user-defined thresholds (default: 70%).
Can the wetted-path sanitization cycle be validated for GMP environments?
Yes—sanitization parameters (temperature, duration, chemical concentration if applicable) are logged with timestamps and can be exported for inclusion in equipment qualification protocols (IQ/OQ/PQ).
Is the integrated purification cartridge compatible with third-party water pretreatment systems?
Yes—the GenPure xCAD accepts feed water from any RO or EDI system meeting ASTM D1193 Type II specifications; inlet pressure and flow rate tolerances are documented in the technical manual.
What is the calibration interval recommendation for the TOC analyzer?
Annual calibration using certified sucrose standards (1–5 ppb range) is recommended; calibration certificates include uncertainty budgets compliant with ISO/IEC 17025.
