ANYAN AYAN-B150 Short-Path Molecular Distillation System

Overview

The ANYAN AYAN-B150 Short-Path Molecular Distillation System is a precision vacuum separation instrument engineered for high-efficiency thermal separation of heat-sensitive, high-boiling-point, or oxidation-prone liquid mixtures. Unlike conventional distillation—operating near atmospheric boiling points—the AYAN-B150 functions under ultra-high vacuum (≤0.1 Pa), enabling molecular evaporation at significantly reduced temperatures. This principle relies on the kinetic mean free path of vapor molecules exceeding the physical distance between the evaporator surface and the internal condenser, thereby allowing selective volatilization based on molecular weight, polarity, and vapor pressure differentials. The system integrates a mechanically driven PTFE-coated SS316L刮板 rotor to generate a uniform, sub-0.5 mm liquid film on the heated cylindrical wall, minimizing thermal exposure time to 5–15 seconds while maximizing interfacial heat transfer. Designed for laboratory-scale process development and pilot validation, it supports scalable parameter optimization for downstream industrial implementation in pharmaceutical purification, nutraceutical concentration, specialty chemical refinement, and essential oil fractionation.

Key Features

• Ultra-high vacuum capability: Base pressure ≤0.1 Pa, ensuring minimal thermal degradation and oxidative side reactions
• Thin-film generation via dual-material刮板 assembly: PTFE-sheathed SS316L rotor provides exceptional corrosion resistance and consistent film thickness control
• Adjustable feed preheating: Integrated jacketed feed tank with PID-controlled temperature regulation (up to 200 °C)
• Fluoroelastomer (FKM) gasket sealing at all flanged interfaces; optional perfluoroalkoxy (PFA) film seals available for aggressive solvent applications
• Modular design accommodating customizable heating surface areas (standard F = 0.4 m²; larger configurations available upon request)
• No boiling or bubbling phenomena: Surface-only free evaporation eliminates nucleate boiling, preserving structural integrity of labile compounds
• Physically clean separation: Solvent-free, residue-free operation compliant with ISO 22000 and USP principles for non-thermal processing

Sample Compatibility & Compliance

The AYAN-B150 is validated for use with thermally unstable actives—including polyphenols, unsaturated fatty acids, terpenoids, and labile alkaloids—as well as viscous feedstocks (up to 50,000 cP) and suspensions containing fine particulates or microcrystals. Its construction adheres to ASME BPVC Section VIII Div. 1 pressure boundary requirements for vacuum vessels and incorporates traceable material certifications (EN 10204 3.1) for all wetted SS316L components. The system meets ASTM D2879-18 guidelines for molecular distillation performance verification and supports GLP-compliant operation when paired with external data loggers meeting FDA 21 CFR Part 11 audit trail requirements. All elastomeric seals comply with USP Class VI biocompatibility standards.

Software & Data Management

While the base AYAN-B150 operates via analog front-panel controls (digital vacuum gauge, temperature controllers, variable-speed motor drive), optional RS485/Modbus RTU integration enables connection to third-party SCADA or LIMS platforms. Real-time acquisition of vacuum level, jacket temperature, feed rate, and rotor speed is supported for batch record generation. For full digital traceability, users may deploy external validated software (e.g., LabArchives ELN or DeltaV DCS modules) to capture time-stamped operational parameters, ensuring alignment with GMP Annex 11 and ISO/IEC 17025 documentation protocols. No embedded firmware stores raw process data locally; all critical settings are manually recorded per batch to maintain regulatory flexibility.

Applications

• Purification of omega-3 concentrates (EPA/DHA) from fish oil hydrolysates without cis-trans isomerization
• Deodorization and decolorization of vegetable-based carrier oils (e.g., MCT, squalane) prior to cosmetic formulation
• Isolation of monoterpenes (limonene, pinene) from citrus peel extracts under oxygen-limited conditions
• Removal of residual solvents (hexane, ethyl acetate) from botanical extracts post-SFE or maceration
• Concentration of heat-labile enzyme inhibitors from microbial fermentation broths
• Multi-stage fractionation of polymer oligomers (e.g., polycaprolactone diols) by molecular weight cutoff

FAQ

What distinguishes short-path molecular distillation from conventional thin-film evaporation?

Short-path systems operate at pressures below 0.001 mbar with an integrated condenser positioned <10 cm from the evaporator surface, enabling direct molecular flight paths. Conventional thin-film evaporators typically operate above 1 mbar and rely on external condensers, resulting in higher thermal stress and longer residence times.

Can the AYAN-B150 handle crystallizing or fouling feeds?

Yes—the SS316L/PTFE刮板 design resists scaling and accommodates slurries with ≤15 wt% solids. Optional ultrasonic assist nozzles (not included) can be retrofitted to mitigate crystal adhesion during prolonged runs.

Is validation support provided for regulatory submissions?

ANYAN supplies material traceability dossiers, pressure vessel certification documents, and IQ/OQ protocol templates compatible with EU GMP Annex 15 and FDA Process Validation Guidance. PQ execution remains user-responsible per site-specific risk assessment.

What maintenance intervals are recommended for continuous operation?

Vacuum pump oil replacement every 500 hours; rotor bearing inspection every 2,000 hours; FKMs seal replacement every 18 months under standard solvent exposure. Full service manual includes torque specifications and leak-check procedures using helium mass spectrometry.