ROCKER BioVac 300 Triple-Position Stainless Steel Filtration Manifold

Overview

The ROCKER BioVac 300 Triple-Position Stainless Steel Filtration Manifold is an engineered solution for high-integrity, repeatable vacuum-driven filtration in regulated and research-intensive life science laboratories. Designed around Couette-flow–compatible vacuum manifold architecture, it enables simultaneous or independent processing of up to three liquid or air samples under controlled negative pressure—without cross-contamination or pressure bleed between channels. Its fully welded SUS316 stainless steel construction ensures compatibility with aggressive solvents, acidic or alkaline media, and repeated sterilization cycles including steam autoclaving (121 °C, 20 min), dry-heat ovens (up to 250 °C), and direct flame passivation. Unlike polymer-based manifolds, the BioVac 300 eliminates leachables, extractables, and dimensional creep during thermal cycling—critical for USP , ISO 10993, and FDA 21 CFR Part 11–aligned workflows requiring material traceability and long-term stability.

Key Features

• Triple-position configuration with fully independent manual isolation valves—each valve constructed from monolithic SUS316, enabling true channel-to-channel separation during multi-step protocols (e.g., sequential filtration of different sample matrices or parallel validation runs)
• Patented twist-lock coupling mechanism (Taiwan Patent No. M381450) eliminates reliance on external clamps or torque-sensitive fasteners; achieves leak-tight seal at ≤3000 psi with ≤2.5 turns per position—validated per ASTM F2391 for vacuum integrity
• Universal cup interface accepts standard 47 mm and 50 mm diameter membranes across three interchangeable cup sizes: 500 mL, 750 mL, and 1000 mL—enabling scalability from small-volume QC assays to large-batch environmental sampling
• Integrated 8 mm (5/16″) barbed inlet ports with precision-machined O-ring grooves ensure secure tubing retention without adhesives or secondary fixtures—compatible with silicone, fluoropolymer, and reinforced PVC vacuum lines
• Zero dead-volume design at filter seat interface minimizes sample hold-up and facilitates complete membrane retrieval post-filtration—essential for microbial colony enumeration (ISO 7218, AOAC 977.27) and particulate recovery studies

Sample Compatibility & Compliance

The BioVac 300 supports a broad range of sample types—including aqueous suspensions, organic solvents (e.g., acetone, ethanol, ethyl acetate), buffered saline solutions, fermentation broths, and aerosolized particulates—without degradation of structural integrity or surface passivation. All wetted surfaces conform to ASTM A276 and EN 10088-3 specifications for austenitic stainless steel. The manifold meets mechanical requirements for GLP-compliant environments per OECD Series 1, and its material certification package includes mill test reports (MTRs) traceable to heat number. When used with certified sterile-filter cups and validated 0.22 µm or 0.45 µm membranes, the system satisfies ISO 13408-1 for aseptic processing and USP sterility testing applications.

Software & Data Management

As a standalone vacuum manifold, the BioVac 300 operates without embedded electronics or firmware—ensuring electromagnetic compatibility (EMC) in sensitive instrumentation suites and eliminating software validation burdens under GMP Annex 11 or FDA 21 CFR Part 11. Process documentation is maintained externally via laboratory notebooks, LIMS-integrated SOPs, or electronic batch records. Optional integration with ROCKER’s BioVac Control Hub (sold separately) enables analog vacuum gauge readouts and centralized shutoff—but no data logging, audit trail, or user authentication is natively provided, preserving regulatory neutrality for labs requiring minimal computerized system validation.

Applications

• Microbiological analysis: Membrane filtration for total viable count (TVC), coliform detection (ISO 9308-1), and waterborne pathogen concentration (EPA Method 1623)
• Pharmaceutical quality control: Sterility testing of injectables, ophthalmic solutions, and parenteral excipients per USP
• Environmental monitoring: Air sampling for bioaerosols (ISO 14698-1), wastewater particulate capture, and soil leachate clarification
• Bioprocess development: Clarification of cell culture harvests, buffer exchange pre-chromatography, and tangential flow ultrafiltration (TFF) feed stream conditioning
• Chemical R&D: Solvent-resistant particulate removal in catalyst recovery, polymer solution degassing, and reaction mixture workup

FAQ

Is the BioVac 300 compatible with vacuum pumps rated above 3000 psi?
No—the manifold is rated for maximum operating pressure of 3000 psi (207 bar) absolute vacuum; exceeding this may compromise valve sealing integrity or cause microfracture in SUS316 weld zones.
Can I use non-ROCKER branded filter cups with this manifold?
Yes—if the cup features standardized 47/50 mm membrane seating, 8 mm inlet port geometry, and SUS316 or equivalent corrosion-resistant construction; however, ROCKER-certified cups guarantee full compliance with twist-lock engagement and pressure-rated sealing.
Does the 2-year warranty cover labor or only parts?
The warranty covers replacement of defective components only; field service labor, shipping, or calibration verification are excluded unless contracted separately under ROCKER’s Premium Support Program.
How is sterilization validation performed for this manifold?
Users must conduct cycle-specific validation (e.g., BI challenge, temperature mapping, leak testing per ISO 17665-1) using their own autoclave or dry-heat oven; ROCKER provides material certificates but does not supply pre-validated sterilization protocols.
Are replacement gaskets and O-rings available as spare parts?
Yes—SUS316-compatible Viton® and EPDM O-rings (P/N: 167110-20-OR), along with calibrated valve stem assemblies, are stocked globally and listed in ROCKER’s official spare parts catalog (Rev. 2024.3).