ORGANO PR-FP-0120a-UT1 Ultra Pure Water System
| Brand | ORGANO |
|---|---|
| Origin | Japan |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | PR-FP-0120a-UT1 |
| Purified Water Grade | ASTM Type I / ISO 3696 Grade 1 |
| Resistivity | 18.2 MΩ·cm @ 25°C |
| Heavy Metals & Soluble Silica | <3 ng/L (Detection Limit) |
| TOC | Real-time online measurement, <5 ppb typical |
| Endotoxins | <0.001 EU/mL |
| Particles (>0.1 µm) | <1 particle/mL |
| Flow Rate | 0.016–2 L/min (via dedicated dispensing arm) |
| Daily Output Capacity | ≥45 L |
| Feed Water | Municipal tap water (pre-treated) |
Overview
The ORGANO PR-FP-0120a-UT1 Ultra Pure Water System is a benchtop-grade, integrated purification platform engineered for laboratories requiring consistent, trace-level purity in analytical and life science applications. It employs a multi-stage purification architecture grounded in sequential ion exchange, ultraviolet photo-oxidation (185/254 nm), and ultrafiltration—designed to meet and exceed ASTM D1193 Type I, ISO 3696 Grade 1, and CLSI EP21-A standards for ultrapure water. The system is specifically validated for use in sensitive downstream processes including ICP-MS, HPLC-MS, cell culture media preparation, molecular biology workflows (e.g., PCR, sequencing, transfection), and pharmaceutical stability testing. Its core design prioritizes chemical inertness, low extractables, and structural integrity—utilizing PFA, EPDM-free wetted materials and electropolished 316L stainless steel components where applicable.
Key Features
- Two-stage high-capacity mixed-bed ion exchange resin with optimized regeneration kinetics, delivering stable resistivity ≥18.2 MΩ·cm at 25°C and minimizing organic leachables.
- Integrated 185/254 nm dual-wavelength UV lamp for continuous photolytic oxidation of organic contaminants, reducing TOC to sub-5 ppb levels in real time.
- 0.1 µm ultrafiltration (UF) membrane module certified for removal of DNase, RNase, endotoxins, and microbial particles—critical for sterile and nuclease-free applications.
- Onboard real-time TOC analyzer with NDIR detection and automatic calibration, providing traceable, audit-ready TOC data synchronized with system logs.
- Full-spectrum elemental contaminant monitoring capability: validated detection limits ≤3 ng/L for Na, K, Ca, Mg, Fe, Cu, Zn, Ni, Pb, Cr, Mn, Al, Ti, B, and soluble silica—verified per ICP-MS methodology.
- Programmable dispensing interface supporting volumetric, timed, and continuous modes; flow rate precisely adjustable from 1 mL/min to 2 L/min via integrated pressure-regulated dispensing arm.
Sample Compatibility & Compliance
The PR-FP-0120a-UT1 accepts municipal tap water as feedstock following standard pretreatment (e.g., activated carbon + sediment filtration). It is CE-marked and compliant with IEC 61010-1 for laboratory equipment safety. Water quality output satisfies regulatory expectations for GLP and GMP environments: full audit trail support (including user login, parameter changes, maintenance events), electronic signature readiness per FDA 21 CFR Part 11 (when deployed with validated networked software), and documentation alignment with ISO/IEC 17025 requirements for calibration traceability. Endotoxin and nuclease specifications conform to USP and , respectively.
Software & Data Management
The system features an embedded touchscreen HMI with intuitive navigation and multilingual UI (English, Japanese, Chinese). All critical parameters—including resistivity, TOC, temperature, UV intensity, UF differential pressure, and cartridge service life—are logged at 1-minute intervals and exportable via USB or Ethernet (Modbus TCP). Optional cloud-based remote monitoring enables predictive maintenance alerts and centralized fleet management across multiple instruments. Data files are generated in CSV and PDF formats compatible with LIMS integration and internal QA review workflows.
Applications
- Trace-metal analysis by ICP-MS and GF-AAS, where sub-ng/L background contamination is essential.
- High-resolution liquid chromatography (UHPLC, LC-MS) mobile phase and blank preparation.
- Preparation of electrophysiology buffers, stem cell culture media, and monoclonal antibody formulation solutions.
- Genomic applications requiring DNase/RNase-free water: cDNA synthesis, CRISPR editing, single-cell RNA-seq library prep.
- Pharmaceutical QC testing per USP and EP 2.2.44 for purified water qualification.
- Calibration standard dilution in reference material laboratories accredited to ISO/IEC 17025.
FAQ
What feed water quality is required prior to connection?
Municipal tap water meeting local drinking water standards is acceptable, provided it passes a prefilter (5 µm sediment + activated carbon) to remove chlorine, particulates, and organics. Hardness should be <200 ppm CaCO₃.
Is the system suitable for cleanroom environments?
Yes—the PR-FP-0120a-UT1 operates silently (<45 dB(A)), has zero volatile emissions, and supports point-of-use installation with Class 100 (ISO 5) compatible dispensing arms and HEPA-filtered air purge options.
How often must consumables be replaced?
Resin cartridges require replacement every 6–12 months depending on feed water quality and daily usage volume; UF membranes are rated for ≥12 months or 10,000 L throughput; UV lamps are replaced annually or after 9,000 hours of operation.
Does the system support IQ/OQ/PQ documentation packages?
Yes—ORGANO provides vendor-validated qualification protocols (IQ/OQ), test scripts, and blank PQ forms aligned with ASTM E2500 and Annex 15 guidelines, available upon request for regulated users.
Can the TOC sensor be recalibrated onsite?
Yes—the NDIR-based TOC analyzer includes built-in zero/span verification using certified potassium hydrogen phthalate (KHP) standards and supports user-initiated calibration with traceable reference materials.
