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| Brand | Leica |
|---|---|
| Origin | Germany |
| Model | TCS SP8 DLS |
| Imaging Principle | Orthogonal light-sheet illumination integrated with confocal detection |
| Brand | Leica |
|---|---|
| Origin | Germany |
| Model | TCS SP8 CARS |
| Laser Modalities | Visible, UV, IR, SHG, CARS |
| Imaging Modes | Single-photon fluorescence, multiphoton fluorescence, CARS, SHG, spectral unmixing |
| Scan Systems | Dual scanning architecture (standard resonant + high-speed resonant/galvo) |
| Software Platform | LAS X (successor to LAS AF), FDA 21 CFR Part 11 compliant modules available |
| Compliance | ISO 13485–certified manufacturing, CE-marked, GLP/GMP-ready audit trail support |
| Brand | Leica |
|---|---|
| Origin | Germany |
| Model | TCS SP8 SMD |
| Application Domain | Single-Molecule Detection (SMD), Fluorescence Correlation Spectroscopy (FCS), Fluorescence Cross-Correlation Spectroscopy (FCCS), Fluorescence Lifetime Imaging Microscopy (FLIM), Fluorescence Lifetime Correlation Spectroscopy (FLCS) |
| Integrated Hardware Platform | PicoQuant MD-series detection modules and timing electronics |
| Software Integration | PicoQuant SymPhoTime 64 (SMD-optimized edition) |
| Optical Architecture | Inverted confocal platform with tunable white-light laser (WLL), spectral detection (HyD detectors), and time-correlated single-photon counting (TCSPC) capability |
| Compliance | Designed for GLP/GMP-aligned workflows |
| Brand | Leica |
|---|---|
| Origin | Germany |
| Model | STELLARIS CRS |
| Instrument Type | Point-Scanning Confocal Microscope |
| Excitation | Near-Infrared (NIR) Lasers |
| Imaging Modalities | Stimulated Raman Scattering (SRS), Coherent Anti-Stokes Raman Scattering (CARS), Multiphoton Fluorescence, Second Harmonic Generation (SHG), FLIM |
| Spatial Resolution | Subcellular (≤ 300 nm lateral, ≤ 1 µm axial) |
| Detection | Spectral Unmixing, TauSense Lifetime-Gated Acquisition |
| Software Platform | LAS X with ImageCompass Interface |
| Compliance | Designed for GLP/GMP-aligned workflows |
| Brand | Leica |
|---|---|
| Origin | Germany |
| Model | TCS SP8 MP |
| Instrument Type | Point-Scanning Multiphoton Confocal Microscope |
| Excitation Range | 680–1300 nm |
| Maximum IR Wavelength | 1300 nm |
| Resonant Scanner Speed | 8 kHz / 12 kHz |
| Field of View (FOV) | up to 22 mm |
| Detection | Leica HyD NDD & HyD RLD non-descanned detectors |
| Objective Correction | motCORR electrically adjustable correction collar |
| Specialized Objectives | HC IRAPO L 25×/1.00 W motCORR, HC FLUOTAR L 25×/1.00 IMM (ne=1.457) motCORR VISIR, APO HCX L20×/0.95 IMM for BABB immersion (ne=1.559) |
| Software Platform | LAS X with integrated multiphoton control, FLIM wizard, and STED/FLIM/SMD module compatibility |
| Compliance | Designed for GLP/GMP-aligned workflows |
| Brand | Leica |
|---|---|
| Country of Origin | Germany |
| Model | STELLARIS STED |
| Excitation Wavelength Range | 440–790 nm (White Light Laser) |
| STED Depletion Wavelengths | 592 nm, 660 nm, 775 nm |
| Spatial Resolution | <30 nm (lateral), <100 nm (axial), sample- and fluorophore-dependent |
| Detection | Up to 5 spectral Power HyD detectors with 1.5 ns system dead time |
| Objective Options | STED WHITE 100× oil, 93× glycerol (motCORR), 86× water (motCORR) |
| Brand | Leica |
|---|---|
| Origin | Germany |
| Model | STELLARIS Cryo |
| Application Domain | Cryo-Correlative Light and Electron Microscopy (Cryo-CLEM) |
| Cooling Stage | Integrated Liquid Nitrogen–Cooled Stage with Transfer Shuttle |
| Software Platform | LAS X Coral Cryo (with TauSense, LIGHTNING, and Interpolated 3D Targeting) |
| Objective Lens | HC PL APO 50×/0.90 Cryo-Optimized Dry Objective |
| Detection System | Power HyD Hybrid Detectors |
| Light Source | White Light Laser (WLL, 470–670 nm) |
| Imaging Modes | Confocal Reflectance, Fluorescence, TauContrast, TauSeparation, Spectral Unmixing |
| Ice Thickness Assessment | Dual-mode (Overview + Confocal Reflectance Z-Stack) |
| Data Format | Open, Metadata-Rich TIFF & HDF5 (CF-1 compliant) |
| Regulatory Alignment | Designed for GLP/GMP-aligned workflows |
| Brand | Leica |
|---|---|
| Origin | Germany |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | MICA Widefield-Confocal |
| Instrument Type | Point-Scanning Confocal Microscope |
| Lasers | 405 nm, 488 nm, 561 nm, 638 nm |
| Fluorescence Detectors | Standard configuration with four HyD detectors and four sCMOS cameras |
| Optical Zoom | 1–6× |
| Microscope Host | Fully motorized inverted fluorescence microscope |
| Illumination Sources | Laser + LED |
| Software & Workstation | Intuitive GUI with integrated Pixel Classifier AI module |
| Vibration Isolation | Passive anti-vibration table |
| Brand | Leica |
|---|---|
| Origin | Germany |
| Model | STELLARIS 8 DIVE |
| Instrument Type | Point-Scanning Confocal Microscope |
| Excitation Range | Up to 1300 nm |
| Detection Range | 380–800 nm (tunable via 4Tune spectral detector) |
| Core Technology | Tunable non-descanned spectral detection with variable beam expander (VBE) |
| Compliance | Designed for GLP/GMP-aligned workflows |
| Brand | Leica |
|---|---|
| Origin | Germany |
| Model | TCS SP8 X |
| Excitation Source | Tunable White Light Laser (WLL), Pulsed |
| Detection Channels | Up to 5 Spectral Detection Channels |
| Excitation Lines | Up to 8 Simultaneous Lines |
| FLIM Compatibility | Yes, with Adjustable Repetition Rate via Pulse Picker |
| LightGate Technology | Time-Gated Spectral Detection |
| Spectral Resolution | Continuous Excitation & Emission Acquisition (Excitation–Emission Matrix Mapping) |
| Application Scope | Live-Cell Imaging, Multicolor Fluorescence, Spectral Unmixing, FLIM, pH/Binding Microenvironment Analysis |
| Brand | Leica |
|---|---|
| Country of Origin | Germany |
| Model | Leica STELLARIS STED |
| Instrument Type | Point-Scanning Confocal Microscope |
| STED Laser Wavelengths | 592 nm, 660 nm, 775 nm |
| Excitation Range | 440–790 nm (White Light Laser) |
| Detection | Up to 5 spectral Power HyD detectors (HyD S/X/R), 1.5 ns system dead time |
| Objective Support | STED-optimized STED WHITE 100× oil, 93× glycerol (motCORR), 86× water (motCORR) |
| Resolution | <30 nm lateral, <100 nm axial (sample- and fluorophore-dependent) |
| Core Technology | Time-gated STED (TauSTED Xtend), TauSense-enabled lifetime discrimination, FLIM-capable with FALCON module |
| Software Platform | LAS X with ImageCompass, LAS X Navigator, TauSense tools |
| Brand | Leica |
|---|---|
| Origin | Germany |
| Model | Leica SR GSD |
| Laser Wavelengths | 405 nm, 488 nm, 532 nm, 642 nm |
| Laser Power | 300–1000 mW per line |
| Lateral Drift Stability | <20 nm / 10 min (SuMo Piezo Stage) |
| Resolution (GSDIM mode) | ≤20 nm (lateral) |
| Compatible Fluorophores | Alexa Fluor® 488/532/546/647, Rhodamine-6G, Atto 488/532/565/568, YFP, EYFP |
| Imaging Modes | Widefield, TIRF, High-Speed Multichannel Fluorescence, Temperature-Controlled Live-Cell Imaging |
| Base Platform | Leica DMI6000 B Inverted Microscope with AM TIRF MC System |
| Brand | Leica |
|---|---|
| Origin | Germany |
| Model | STELLARIS 8 FALCON |
| Imaging Modality | Time-Correlated Single-Photon Counting (TCSPC)-based Fluorescence Lifetime Imaging (FLIM) |
| Frame Rate | Up to 4 fps at 256 × 256 pixels |
| Spectral Channels | Simultaneous acquisition across up to 4 spectral detection channels or sequential acquisition across up to 10 channels |
| FLIM Analysis Modes | Biexponential decay fitting, phasor plot analysis, spectral-FLIM unmixing |
| Software Integration | Fully embedded in Leica LAS X NAVIGATOR and LAS X LITE platforms |
| Compliance | Designed for GLP/GMP-aligned workflows |
| Brand | Leica |
|---|---|
| Origin | Germany |
| Instrument Type | Point-Scanning Confocal Microscope |
| Model | STELLARIS SpectraPlex |
| Spectral Unmixing Capacity | >15 fluorophores per acquisition |
| Workflow Integration | Aivia AI-powered analysis platform |
| Compliance | Designed for GLP/GMP-aligned spatial biology workflows, compatible with ISO 13485–informed documentation practices |
| Brand | Leica |
|---|---|
| Origin | Germany |
| Instrument Type | Point-Scanning Confocal Microscope |
| Model | STELLARIS |
| Detection Range | 410–850 nm |
| Excitation Source | White Light Laser (WLL), up to 8 simultaneous spectral lines |
| Detector Technology | Power HyD hybrid detectors |
| Core Capabilities | Fluorescence Lifetime Imaging (FLIM), TauSense-based functional contrast, AI-driven rare-event detection (Aivia), 3D optical sectioning, multi-modal integration (STED, DIVE, DLS, FALCON, CARS) |
| Brand | Leica |
|---|---|
| Country of Origin | Germany |
| Model | STELLARIS DLS |
| Instrument Type | Point-Scanning Confocal Microscope with Integrated Digital Light Sheet Module |
| Integration Compatibility | STELLARIS 5 and STELLARIS 8 platforms |
| Optical Architecture | Inverted microscope with vertical dual-axis light sheet generation via TwinFlect mirror system |
| Illumination | Scanned Gaussian or top-hat light sheet (405–785 nm excitation range) |
| Detection | Dual sCMOS cameras (optional high-speed or high-sensitivity configuration) |
| Sample Mounting | Standard glass-bottom dishes, U-shaped capillaries, FEP tubing, or custom mounting frames (24 × 50 mm rectangular / Ø30 mm circular) |
| Refractive Index Matching | Compatible with water, glycerol, BABB, Scale, CUBIC, and other clearing media |
| Software Platform | LAS X LightSheet Wizard with real-time fusion, environmental control module, 3D Visualization, and GLP-compliant audit trail (21 CFR Part 11 ready) |
| Brand | Leica |
|---|---|
| Origin | Germany |
| Model | Leica SD AF |
| Configuration | Import (OEM-manufactured in Germany) |
| Software Platform | Leica MM AF |
| Core Technology | Yokogawa CSU-X1 Spinning Disk Unit Integrated with Leica Optical Path and Adaptive Focus Control |
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