Molecular Interaction Analyzer
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| Brand | Affinité |
|---|---|
| Origin | Canada |
| Model | P4SPR, P4PRO |
| Instrument Type | Surface Plasmon Resonance (SPR) |
| Channel Configuration | 4-channel (3 sample + 1 reference) |
| Detection Range | >88 Da |
| Sample Volume | 100 µL |
| Injection Volume | 10–200 µL |
| Analysis Time | 10 min |
| Temperature Control | Ambient |
| Light Source | Multicolor LED (550–750 nm) |
| Detector | High-uniformity gold thin-film sensor |
| Refractive Index Range | 1.333–1.390 RIU |
| Association Rate (kₐ) | 10³–10⁹ M⁻¹s⁻¹ |
| Dissociation Rate (k_d) | 10⁻⁶–10⁻¹ s⁻¹ |
| Affinity Range | pM–mM |
| Dimensions | ≤175 × 155 × 55 mm |
| Weight | <1.3 kg |
| Brand | Beckman Coulter |
|---|---|
| Origin | USA |
| Manufacturer | Beckman Coulter, Inc. |
| Product Type | Imported Instrument |
| Model | OPTIMA AUC |
| Detection Range | 5 µg/mL – 150 mg/mL |
| Sample Volume | 380 µL |
| Analysis Duration | Hours (typically 2–8 h per run) |
| Temperature Control Range | 0–40 °C |
| Detection Modes | UV-Vis Absorbance (190–800 nm) and Interference Optics |
| Simultaneous Wavelengths | Up to 20 |
| Maximum Rotor Capacity | 8 cells (An-50 Ti rotor) |
| Throughput | Up to 7 samples per run (standard configuration), up to 21 sample conditions via sequential or multi-temperature protocols |
| Origin | USA |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | BI-2500 |
| Detection Range | <100 Da, KD = 10⁻³ M (1 mM) to 10⁻¹² M (1 pM), angular resolution <10⁻⁴° |
| Sample Channels | 3 |
| Injection Volume | >50 µL |
| Analysis Time Scale | milliseconds to hours (kinetically resolved) |
| Temperature Control | Ambient only |
| Origin | USA |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | BI-4500 |
| Price Range | USD 70,000 – 140,000 |
| Sample Flow Channels | 5 |
| Light Source | Dual 670 nm LEDs |
| Detection Speed | 4 ms |
| Incident Angle Range | 40–47° (gas phase), 67–81° (liquid phase) |
| Sensitivity | < 0.06 RU RMS (0.01 mdeg RMS) |
| Drift | ≤ 1 RU/hour (≤ 0.17 mdeg/hour) under ambient temperature drift < 1 °C/hour |
| Interface | USB 3.0 |
| Dimensions | 355 × 250 × 515 mm (W × H × D) |
| Weight | 11.5 kg |
| Brand | BI/Biosensing Instrument |
|---|---|
| Origin | USA |
| Model | BI-4500 |
| Detection Principle | Surface Plasmon Resonance (SPR) |
| Optical Wavelength | 670 nm |
| Angular Resolution | <0.01 mDeg RMS |
| Sensitivity | <0.06 RU RMS |
| Flow Channels | 5 independent microfluidic channels |
| Flow Rate Range | 1.0–250 µL/min |
| Minimum Analyte MW | 100 Da |
| Injection Volume | >50 µL |
| Injection Time | <0.2 s |
| Liquid-Phase Incident Angle Range | 67–81° |
| Gas-Phase Incident Angle Range (optional) | 40–47° |
| BI-DirectFlow™ Technology | Yes |
| Software Compliance | FDA 21 CFR Part 11 ready (audit trail, electronic signature support), GLP/GMP-compatible data handling |
| Brand | Bionavis |
|---|---|
| Origin | Finland |
| Model | MP-SPR Navi 200 OTSO |
| Sample Volume | 250 µL |
| Injection Volume | 50 µL |
| Analysis Time | 5–10 min |
| Temperature Control Range | 15–45 °C (ambient ±7 °C / +20 °C) |
| Brand | Bionavis |
|---|---|
| Origin | Finland |
| Model | MP-SPR Navi 210A VASA |
| Sample Volume | 250 µL |
| Injection Volume | 50 µL |
| Analysis Time | 5–10 min |
| Temperature Control Range | 15–45 °C (ambient ±7 °C / +20 °C) |
| Brand | Bionavis |
|---|---|
| Origin | Finland |
| Model | MP-SPR Navi 220A NAALI |
| Sample Volume | 250 µL |
| Injection Volume | 50 µL |
| Analysis Time | 5–10 min |
| Temperature Control Range | 15 °C–45 °C (ambient ±7 °C / +20 °C) |
| Angular Scan Range | 40°–78° |
| Angular Resolution | 0.001° |
| Laser Wavelengths | 670 nm (standard), optional dual-wavelength (670 nm + 785 nm) |
| Refractive Index Range | 1.00–1.40 (bulk), extendable for high-RI materials (e.g., diamond-like carbon, n ≈ 2.7) |
| Flow Rate | 1–1000 µL/min |
| Sensitivity | 1 µRIU (refractive index unit), 1 pg/mm² (protein surface coverage) |
| Kinetic Range | kₐ = 10³–10⁸ M⁻¹s⁻¹, k = 10⁻⁷–0.1 s⁻¹, K_D = 10⁻¹²–10⁻³ M |
| Detection Limit | <100 Da (liquid phase), H₂ (2 Da, gas phase) |
| Noise | Short-term ≤0.3 µRIU, Drift <1 µRIU/min |
| Flow Channels | 2 independent, switchable in series or parallel |
| Sensor Chip Compatibility | Au, Ag, Cu, Pt, SiO₂, Al₂O₃, TiO₂, CMD, Ni²⁺, custom functionalized surfaces |
| Flow Cell Options | PDMS (1 µL/channel), PEEK (SPR305-MS), electrochemical (SPR321-EC), gas-phase (SPR310-GS), fast-kinetics (SPR302-LS), or custom |
| Brand | Bionavis |
|---|---|
| Origin | Finland |
| Model | MP-SPR Navi 400 KONTIO |
| Sample Volume | 250 µL |
| Injection Volume | 50 µL |
| Analysis Time | 5–10 min |
| Temperature Control Range | 15–45 °C |
| Angular Measurement Range | 40–78° |
| Angular Resolution | 0.001° |
| Flow Rate | 10–400 µL/min |
| Laser Wavelengths | 670 nm (standard), optional dual-wavelength (670 nm + 785 nm) |
| Refractive Index Range | 1.00–1.40 (bulk), extendable for high-RI materials (e.g., diamond-like carbon, n ≈ 2.7) |
| Thickness Measurement Range | Å to µm (material-dependent) |
| Kinetic Constants | kₐ = 10³–10⁸ M⁻¹s⁻¹, k = 10⁻⁷–0.1 s⁻¹, K = 10⁻¹²–10⁻³ M |
| Sensitivity | 1 µRIU, 1 pg/mm² (protein coverage) |
| Minimum Detectable Mass | 2 Da (gas phase), <100 Da (liquid phase) |
| Short-term Noise | 0.3 µRIU, Baseline Drift: <1 µRIU/min |
| Flow Channels | 4 (PDMS microfluidic cell) |
| Detection Modes | Angle-scan (full SPR curve) and fixed-angle (kinetic mode, up to 1 ms sampling) |
| Brand | Bionavis |
|---|---|
| Origin | Finland |
| Model | MP-SPR Navi 410A KAURIS |
| Sample Volume | 250 µL |
| Injection Volume | 50 µL |
| Analysis Time | 5–10 min |
| Temperature Control Range | 15–45 °C (ambient ±7 °C / +20 °C) |
| Angular Measurement Range | 40–78° |
| Angular Resolution | 0.001° |
| Flow Rate | 1–1000 µL/min |
| Laser Wavelengths | 670 nm (standard), optional dual-wavelength (670 nm + 785 nm) |
| Refractive Index Range (bulk) | 1.00–1.40 (expandable with multi-wavelength) |
| Thickness Measurement Range | Å to µm (material-dependent) |
| Kinetic Constants | kₐ = 10³–10⁸ M⁻¹s⁻¹, kₑ = 10⁻⁷–0.1 s⁻¹, K<sub>D</sub> = 10⁻³–10⁻¹² M |
| Sensitivity | 1 µRIU |
| minimum detectable mass | <100 Da (liquid phase), 2 Da (gas phase) |
| Short-term Noise | 0.3 µRIU |
| Baseline Drift | <1 µRIU/min |
| Detection Channels | 4 independent flow channels |
| Auto-sampler Capacity | 7 samples |
| Software | MP-SPR Navi™ Control & Data Viewer, TraceDrawer™, LayerSolver™ (optional) |
| Brand | Bionavis |
|---|---|
| Origin | Finland |
| Model | MP-SPR Navi 420A ILVES |
| Sample Volume | 250 µL |
| Injection Volume | 50 µL |
| Analysis Time | 5–10 min |
| Temperature Control Range | 15–45 °C (ambient ±7 °C / +20 °C) |
| Brand | Biosensing Instrument |
|---|---|
| Origin | USA |
| Manufacturer Type | Authorized Distributor |
| Instrument Type | Surface Plasmon Resonance (SPR) |
| Model | SPRm 200 |
| Detection Range | 200 Da |
| Channel Configuration | 5 parallel microfluidic channels |
| Sample Throughput | 384 × 2 (dual-layer microarray format) |
| Injection Volume | 1–1500 µL (application-dependent) |
| Assay Duration | Millisecond to hour-scale (kinetically resolved) |
| Temperature Control Range | 15–40 °C |
| Detection Mode | Simultaneous SPR imaging + brightfield optical microscopy |
| Spatial Resolution | Pixel-level SPR signal mapping (< 2 µm pixel pitch) |
| Brand | Bruker |
|---|---|
| Origin | Germany |
| Model | SPR #64 |
| Instrument Type | Surface Plasmon Resonance (SPR) |
| Channel Configuration | 8-Channel Orthogonal Flow Cell with 64 Sensor Spots |
| Fluidic Flexibility | Up to 8 Simultaneous Buffer Streams |
| Automation Interface | RESTful API & Robotic Integration Ready |
| Sample Format Support | 96-well & 384-well Microplates, Reagent Reservoirs, External Cooling-Compatible Stage |
| Cleaning Mechanism | Integrated Dual-Prism Cartridge with Auto-Clean Protocol |
| Data Output Format | Open HDF5, CSV, and JSON |
| Brand | Cytiva |
|---|---|
| Origin | Sweden |
| Model | Biacore 1K SPR System |
| Configuration | Single-injection needle, six-flow-cell platform |
| Regulatory Readiness | Optional GxP-compliant software package (21 CFR Part 11 audit trail enabled) |
| Software | Biacore Insight™ v3.x |
| Service Support | OptiRun™ lifecycle service program |
| Upgrade Path | Compatible with Biacore 1K+ expansion module for enhanced ligand multiplexing and sample throughput |
| Brand | Cytiva |
|---|---|
| Origin | Sweden |
| Model | Biacore 1K+ SPR System |
| Channel Configuration | Single-needle, 6-flow cell architecture |
| Sample Capacity | Dual 96-well microplate support + dual reagent racks |
| Buffer Selection | Integrated automated buffer selector |
| Temperature Control | Precise thermostatic sample compartment |
| Software Platform | Biacore Insight™ with FDA 21 CFR Part 11-compliant audit trail and GLP/GMP-ready data management |
| Brand | Cytiva |
|---|---|
| Origin | Sweden |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | Biacore 1S+ SPR System |
| Instrument Type | Surface Plasmon Resonance (SPR) |
| Flow Cell Configuration | Six parallel flow cells |
| Detection Range | fM to mM |
| Sample Capacity | Up to two 96-well or 384-well microplates plus 21–43 additional sample positions |
| Analysis Time per Cycle | 2–15 minutes |
| Temperature Control Range | 4–37°C |
| Brand | Cytiva |
|---|---|
| Origin | USA |
| Model | Biacore 8K |
| Sample Capacity | Up to four 96-well, 384-well, or deep-well plates |
| Injection Volume | 1–200 µL |
| Analysis Time per Cycle | 2–15 min |
| Temperature Control Range | 4°C to 40°C |
| Detection Principle | Label-free real-time surface plasmon resonance (SPR) |
| Throughput | Parallel 8-channel fluidics for simultaneous kinetic and affinity analysis |
| Brand | Cytiva |
|---|---|
| Origin | Sweden |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | Biacore 8K+ SPR System |
| Instrument Type | Surface Plasmon Resonance (SPR) |
| Channel Configuration | Multi-channel (8 sample needles, 16 simultaneous interaction channels) |
| Detection Range | fM to mM |
| Sample Capacity | Up to 4,608 samples (12 × 384-well plates or 24 × 96-well plates) |
| Analysis Time per Cycle | 2–15 minutes |
| Temperature Control Range | 4°C to 40°C |
| Brand | Cytiva |
|---|---|
| Origin | USA |
| Model | Biacore S200 |
| Sample Capacity | One 96-well or 384-well microplate |
| Injection Volume | 2–350 µL |
| Analysis Time per Cycle | 2–15 min |
| Temperature Control Range | 4°C to 45°C |
| Detection Limit | No theoretical lower molecular weight limit for analyte binding detection |
| Brand | Cytiva |
|---|---|
| Origin | Sweden |
| Model | Biacore S200 |
| Instrument Type | Label-Free Molecular Interaction Analyzer |
| Application Focus | Fragment-Based Drug Discovery (FBDD), Kinetic & Affinity Analysis, Epitope Mapping, Competitive Binding Assays |
| Regulatory Context | Designed for GLP-compliant workflows |
| Brand | Cytiva |
|---|---|
| Origin | USA |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | Biacore X100 |
| Price Range | USD 135,000–270,000 (estimated FOB) |
| Detection Range | ≥100 Da |
| Sample Capacity | Up to 15 samples per run |
| Injection Volume | 5–90 µL |
| Analysis Time | 2–15 minutes per cycle |
| Temperature Control Range | 4°C to 40°C |
| Brand | Cytiva |
|---|---|
| Origin | Sweden |
| Model | Biacore X100 |
| Instrument Type | Surface Plasmon Resonance (SPR) |
| Channel Configuration | Multi-channel |
| Detection Range | pM–mM |
| Sample Capacity | 15 samples per run |
| Analysis Time | 2–15 minutes per interaction cycle |
| Temperature Control Range | 4–40 °C |
| Brand | HORIBA |
|---|---|
| Origin | France |
| Model | SPRi-EzPlex |
| Sample Volume | 200 µL (standard), optional 100/250/500 µL |
| Temperature Control Range | 15–40 °C, Accuracy: ±0.1 °C, Stability: ±0.01 °C |
| Detection Limit | 5 pg/mm² |
| Minimum Analyte MW | >240 Da |
| Sample Concentration Range | 150 ng/mL (for 100–1000 kDa) to 5 µg/mL (for 4–20 kDa) |
| Brand | HORIBA |
|---|---|
| Origin | France |
| Model | SPRi-OpenPlex |
| Sample Volume | 200 µL (standard), optional 100/250/500 µL |
| Detection Limit | 10 pg/mm² |
| Minimum Analyte MW | >240 Da |
| Sample Concentration Range | 300 ng/mL (for 100–1000 kDa) to 10 µg/mL (for 4–20 kDa) |
| Temperature Control | Not specified in input |
| Compliance | CE-marked, compatible with GLP/GMP workflows requiring audit trails and instrument qualification |
| Brand | Insplorion AB |
|---|---|
| Origin | Sweden |
| Model | Acoulyte |
| Sensor Diameter | 14 mm |
| Substrate | SiO₂-coated QCM-D crystal |
| Sensing Surface | Nanostructured gold |
| Standard Coatings | Si₃N₄, SiO₂, Al₂O₃, TiO₂ |
| Light Source | Tungsten-halogen lamp |
| Wavelength Range | 450–1000 nm |
| LSPR Sensitivity | ≤0.03 monolayer |
| Measurement Spot Diameter | 3 mm |
| Temporal Resolution | 10 Hz (10 samples/s) |
| Typical Noise Level | <0.01 nm |
| Optical Unit Dimensions (W×D×H) | 25×27×9 cm |
| Acoulyte Module Dimensions (W×D×H) | 8×5×3 cm |
| Software | Insplorer (Windows-compatible) |
| Data Export Format | ASCII text |
| Compatible Platforms | Q-Sense Explorer E1 & Analyzer E4 (with Q-Sense Window Module) |
| NPS Sensing Depth | <30 nm |
| QCM-D Hydrodynamic Penetration Depth | >300 nm |
| Simultaneous Output Parameters | LSPR resonance wavelength shift (Δλ), extinction intensity change, frequency shift (Δf), dissipation change (ΔD) |
| Brand | Insplorion AB |
|---|---|
| Origin | Sweden |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | NPS Sensor Chip |
| Pricing | Upon Request |
| Brand | Insplorion AB |
|---|---|
| Origin | Sweden |
| Model | S2 |
| Analysis Time | 2 s |
| Temperature Control Range | 15 °C–45 °C (±0.1 °C stability) |
| Flow Cell | Dual-channel |
| Sample Dead Volume | 20 µL |
| Standard Syringe Volume | 250 µL |
| Typical Flow Rate | 12.5–250 µL/min |
| Standard Loop Volume | 200 µL |
| Sensor Substrate | Fused Silica |
| Sensing Layer | Nanostructured Gold |
| Detection Depth | Up to 30 nm |
| Light Source | Tungsten-Halogen Lamp (≥2000 h lifetime) |
| Measurement Spot Diameter | 1.5 mm |
| Temporal Resolution | Up to 10 Hz |
| Optical Noise | <0.1 nm (at 1 Hz sampling) |
| Sensor Dimensions | 9.5 × 9.5 × 1 mm |
| System Dimensions | 65 × 42 × 36 cm |
| Weight | 30 kg |
| Software | InControl 1.0 (Windows-compatible) |
| Data Output | Proprietary CSV/TSV format |
| Brand | Insplorion AB |
|---|---|
| Origin | Sweden |
| Model | XNano |
| Measurement Principle | Nanoplasmonic Resonance Spectroscopy (NPS) |
| Sample Environment | Liquid or Gas Flow |
| Temperature Range | 25–80 °C (optional up to 250 °C) |
| Chip Substrate | Fused Silica (9.5 × 9.5 × 1 mm) |
| Sensing Surface | Nanostructured Gold |
| Coating Options | Au, SiO₂, Si₃N₄, TiO₂, Al₂O₃ |
| Optical Source | Tungsten-Halogen Lamp (≥2000 h lifetime) |
| Wavelength Range | 450–1000 nm |
| Spot Size | ~2 mm diameter |
| Time Resolution | 10 Hz (10 samples/sec) |
| Noise Level | < 0.01 nm (in liquid, 1 Hz sampling) |
| Flow Cell Volume | ~4 μL |
| Minimum Sample Volume | ~100 μL |
| Typical Flow Rate | 20–100 μL/min |
| Materials | Titanium & Perfluoroelastomer® |
| Dimensions (Measurement Unit) | 31 × 25 × 25 cm |
| Software | Windows-compatible, ASCII output, multi-parameter real-time export (resonance wavelength, linewidth, extinction) |
| Brand | KSV |
|---|---|
| Origin | Finland |
| Model | SPR-NAVI |
| Measurement Principle | Angular-interrogation SPR with rotating laser |
| Wavelength | 670 nm (optional alternate wavelengths available) |
| Angular Resolution | 0.005° |
| Refractive Index (RI) Range | 1.00–1.45 |
| SPR Angle Range | 40–80° |
| Detection Limit | ΔRI = 3 × 10⁻⁶ (equivalent to ~3 pg/mm² for protein adsorption) |
| Flow Cell Volume | 1 µL |
| Sample Volume per Injection | ≥20 µL |
| Temperature Control Range | 8–40 °C (0.5 °C increments) |
| Fluid Handling | Dual-channel, manual 12-port syringe injector |
| Pump | Dual-channel conductive, software-controlled |
| Dimensions (H×W×D) | 38 × 32 × 31 cm |
| Weight | 10 kg |
| Power Supply | 150 W, 100/240 V AC, 50/60 Hz |
| Interface | USB 2.0, Windows OS compatible |